Substitute Daniel Sturridge scored a dramatic winner in injury time to steer England towards a 2-1 win over Wales and top spot in their Group B clash Euro 2016.
Manchester City displayed champions' swagger as they roared clear at the top with a 5-0 trouncing of Burnley but it was drama which engulfed their neighbours Manchester United and Jose Mourinho that dominated the Premier League agenda on Saturday.
Images from the English Premier League matches played on Wednesday
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A fortunate 85th-minute goal from Brazilian Willian earned Premier League champions Chelsea a 1-1 draw at Liverpool on Saturday after Mohamed Salah's 15th goal of the season looked to have given the hosts the three points.
Arsenal stayed ahead of Manchester United in the race to qualify directly for next season's Champions League when they drew 1-1 at Old Trafford on Sunday while Manchester City made sure of their place in the group stage with a 4-2 win at Swansea City.
Harry Kane's magical season continued on Saturday as he celebrated his first senior England call-up with his first Premier League hat-trick.
Match-by-match facts and statistics ahead of the Premier League fixtures on April 28-30
Photos from the English Premier League matches played on Saturday
Not many people talk badly of Pep Guardiola, a sainted figure in football, but Manchester City's manager will find two of his most vocal critics facing him down at Old Trafford on Saturday.
A goal by Sergio Aguero gave Manchester City a 1-0 victory against neighbours Manchester United, who played with 10 men for more than 50 minutes on Sunday.
Six weeks ago, with Newcastle United in the Premier League's relegation zone and still looking for a first win of the season, Alan Pardew seemed highly unlikely to reach his fourth anniversary as manager in December.
Manchester United were denied by a spirited Stoke City performance as Joe Allen pounced late to secure the visitors their first point at Old Trafford since 1989 in a deserved 1-1 Premier League draw.
Four months after quitting Liverpool for Manchester City, Raheem Sterling will have the first opportunity to justify the move by getting one over his former employers when the teams meet at the Etihad Stadium on Saturday.
West Ham United maintained their impressive start to the season when they beat champions Manchester City 2-1 at Upton Park on Saturday to consolidate their place in the top four of the Premier League.
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ManchesterCity's hopes of regaining the Premier League title suffered a potentially grievous blow on Saturday as they were held to a goalless draw by struggling NorwichCity at Carrow Road.
La Liga leaders Real Madrid were thumped 4-0 away by city rivals Atletico Madrid to open up the Spanish title race, while Chelsea strengthened their hold on top spot in the English Premier League after a 2-1 win at Aston Villa.
Chelsea exploited Manchester City's decision to field a weakened team by romping to a 5-1 win in the FA Cup fifth round on Sunday as they joined London rivals West Ham United and Crystal Palace in the quarter-finals.
Following is a match by match look at the English Premier League's season-opening weekend fixtures:
Champions Manchester United beat Premier League leaders Arsenal 1-0 at Old Trafford on Sunday with Robin van Persie once again tormenting his former team mates with a soaring first half header.
Danny Rose scored a second-half equaliser to cancel out James Milner's penalty as Tottenham Hotspur came from behind to draw 1-1 with Liverpool at White Hart Lane on Saturday.
Two superb curling efforts from Jordan Henderson and Philippe Coutinho handed Liverpool a 2-1 home win against Manchester City in the Premier League on Sunday to deliver a thumping blow to Manuel Pellegrini's title aspirations.
Chelsea came from behind to secure a 3-1 win at Manchester City and forge further clear at the top of the Premier League as a dramatic top-of-the-table clash ended in a mass brawl and two City players being sent off on Saturday.
Wayne Rooney struck with a 74th-minute free kick to give England a 1-0 win over 10-man Estonia in a Euro 2016 Group E qualifier on Sunday and move to within six goals of Bobby Charlton's record tally of 49.
The actress talks about her first Hollywood film, the Jude Law, Melissa McCarthy and Jason Stathom starrer Spy.
Chelsea icon Frank Lampard scored for Manchester City to end his old club's perfect start to the Premier League season while Leicester City came from 3-1 down to beat Manchester United 5-3 on a remarkable day in the Premier League on Sunday.
Chelsea's Diego Costa continued his stunning start to life in the Premier League with a hat-trick in a 4-2 comeback win over Swansea City on Saturday that left champions Manchester City staring up the table after a 2-2 draw at Arsenal.
Manchester United won away for the first time this season when they beat Arsenal 2-1 at the Emirates Stadium on Saturday to climb to fourth in the Premier League table.
Photos from the Champions League matches played on Wednesday.
Manchester City's Sergio Aguero scored a hat-trick as coach Pep Guardiola maintained his 100 per cent record at the club with a commanding 4-0 victory against Borussia Moenchengladbach in their rearranged Champions League Group C opener on Wednesday.
Photos from the Champions League matches played across Europe on Tuesday.
2016 is at the halfway stage and the year has already seen some stunning sporting wins, underdogs emerging triumphant on the biggest stages of them all.
Photos from the Euro 2016 qualifying matches played on Sunday.
Images from the Champions League matches played across Europe on Wednesday.
Photos from the Champions League matches played across Europe on Tuesday